Article title: RELATIVE ANTITHROMBOTIC AND ANTIHEMOSTATIC EFFECTS OF PROTEIN C ACTIVATOR VERSUS LOW MOLECULAR WEIGHT HEPARIN IN PRIMATES Short Title: Hemostatic Safety of Protein C Activators

Short Title: Hemostatic Safety of Protein C Activators Authors: András Gruber, Ulla M. Marzec, Leslie Bush, Enrico Di Cera, José A. Fernández, Michelle A. Berny, Erik I. Tucker, Owen J.T. McCarty, John H. Griffin, and Stephen R. Hanson Institutions: From the Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR; the Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO; and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA. Author contributions: AG & EDC designed research; AG, UMM, MAB, OJTM, EIT, & JAF performed research; LB, EDC, JAF, JHG, & SRH contributed vital reagents and analytical tools; AG, OJTM, UMM, & JAF collected data; AG, EDC, OJTM, JHG & SRH analyzed data; AG wrote the paper. Financial support: This work was supported primarily by National Institute of Health Grants HL73813 to Drs. Di Cera and Gruber, HL49413 and HL58141 to Dr. Di Cera. Additional support was provided by grants HL31950, HL52246, and HL63290 to Dr. Griffin, RR00163 to the Oregon National Primate Research Center, and an American Heart Association Grant 0665512Z to Dr. McCarty. Corresponding author: András Gruber, Department of Biomedical Engineering, BME-OGI, Oregon Health & Science University, 3303 SW Bond Ave, Portland, OR 97239. phone: 503 748 1503; fax: 503 748 7038; e-mail: [email protected] Abstract word count: 199 Total text word count: 4973 Scientific heading: Hemostasis, Thrombosis, and Vascular Biology Blood First Edition Paper, prepublished online January 16, 2007; DOI 10.1182/blood-2006-07-035147